Structural Biology of Alzheimer's Disease
Universitat Autònoma de Barcelona (UAB)

Amyloid plaques are one of the characteristic hallmarks in brains affected by Alzheimer's disease. The main component of the amyloid fibrils present in amyloid plaques is the amyloid peptide, one of the major players in the onset and development of the pathology.

Alzheimer's disease affected nearly 50 million people worldwide in 2015 and it is expected to affect more than 130 million by 2050, with most of the increase taking place in middle and low income countries.

Our research group is dedicated to the study of the mechanisms by which amyloid peptides trigger toxicity in the central nervous system and its relationship to other relevant factors in the development of the disease, such as oxidative stress.

Moreover, via an important net of international collaborations, we investigate the use of dendrimers as potential farmacological tools.